The First Trust NYSE Arca Biotechnology ETF seeks to replicate, to the extent possible, the performance of an index of U.S. companies in the biotechnology industry, initially the NYSE Arca Biotechnology Index. *On February 2021, the First Trust AlphaDEX U.S. Materials Sector Index ETF changed its investment objectives to seek to replicate, to the extent possible, the performance of an index of U.S. companies in the biotechnology industry, initially the NYSE Arca Biotechnology Index.